Faculty
Libin Ye
Associate Professor
CONTACT
Office: BSF 216
Phone: (813) 974-6007
Lab: BSF 258-264
Email
Lab website
EDUCATION
- Ph.D., Nanjing Agricultural University, Nanjing, China (2008)
- Postdoctoral Fellow, University of Illinois at Urbana-Champaign, Urbana, USA, 2011-2012
- Postdoctoral Fellow, University of Pittsburgh Medical Center, Pittsburgh, USA, 2012-2013
- Postdoctoral Fellow, University of Toronto, Toronto, Canada, 2013-2018
RESEARCH
GPCRs constitute the largest transmembrane protein family with more than 800 members. They serve as gatekeepers, controlling transduction for a variety of physiological and pathogenic signals, and are involved in almost every aspect of physiological activities in our human body. It is therefore easy to imagine that any GPCR signaling dysfunction probably leads to a disease such as cancer, cardiac failure, neurological diseases, obesity, and infectious diseases, etc. Although only 10% of GPCRs have been subjected to drug discovery, they are already targeted by nearly 35% of FDA-approved medications, indicating a continued tremendous potential in drug discovery. In brief, my lab’s research focuses on
- Developing novel tools in understanding molecular mechanism of GPCR activation,
- Innovating drug discovery platforms, and
- Exploring new medications for GPCR causative diseases.
In addition, we also study a set of dinoflagellate GPCRs related to the red tide blooms, with an aim to improve coastal ecosystem, understand unicellular GPCR in the evolution, and mitigate dino-associated public health issues.
GRADUATE STUDENTS
- Aidan McFarland
- Xudong Wang
- Wenkai Sun
- Nathaniel Hays
Recent Publications
- Maxine Bi, Xudong Wang, Jinan Wang, Jun Xu, Wenkai Sun, Victor Ayo Adediwura, Yinglong Miao*, Yifan Cheng*, and Libin Ye*. Structure and function of an intermediate GPCR-Gabg complex. BioRxiv: doi:
- Heng Liu, Yunpeng Cui, Xue Zhao, Lulu Wei, Xudong Wang, Ning Shen, Timothy Odom, Xuming Li, William Lawless, Wayne Guida, Chuanhai Cao, Libin Ye, Jianfeng Cai*. Helical sulfonyl-γ-AApeptides modulating Aβ oligomerization and cytotoxicity by recognizing Aβ helix. PNAS, 2024, 121,6, e2311733121.
- Xudong Wang, Chris Neale, Soo-Kyung Kim, William A. Goddard, Libin Ye*. Intermediate-state-trapped mutants pinpoint sequential activation process of G protein-coupled receptor. Nature Communications, 2023, 14(1):1325
- Libin Ye*, Xudong Wang, Aidan McFarland, and Jesper J. Madsen. 19F NMR—A promising tool for dynamic conformational studies of G protein-coupled receptors. Structure, 2022, 30(10): 1372-1384 (Review).
- Sriram S.K.S. Narayanan, Xudong Wang, Jose Paul, Vladislav Paley, Zijian Weng, Libin Ye*, Ying Zhong*. Disinfection and electrostatic recovery of N95 respirators by Corona Discharge for safe reuse. Environmental Sciences & Technology, 2021: doi.org/10.1021/acs.est.1c02649.
- Xudong Wang, Aidan McFarland, Jesper J. Madsen, Eric Aalo, Libin Ye*. The potential of 19F NMR application in GPCR biased drug discovery. Trends in Pharmacological Sciences, 2021, 42(1):19-30. (Review)
- Libin Ye, Chris Neale, Adnan Sljoka, Dmitry Pichugin, Nobuyuki Tsuchimura, Sacha T. Larda, Eps van Ned, Regis Pomes, Angel E. Garcia, Roger Sunahara, Oliver P. Ernst, R. Scott Prosser. Bidirectional allosteric modulation of the A2A adenosine G protein-coupledreceptor by physiological cations. Nature Communications, 2018, 9(1):1372
- Taehun Kim, Pedram Mehrabi, Zhong Ren, Adnan Sljoka, Christopher Ing, Alexandr Bezginov, Libin Ye, Regis Pomes, R. Scott Prosser, Emil F Pai. The role of dimer asymmetry and subunit dynamics in enzyme catalysis. Science, 2017,355(6322): DOI: 10.1126/science.aag2355
- Libin Ye, Ned Van Eps, Marco Zimmer, Oliver P. Ernst, R. Scott Prosser. Activation of A2A adenosine G protein-coupled receptor by conformational selection. Nature, 2016,533: 265–268.